Lee Y, et al. - A gender-sensitive resting-state networks (RSN) was analyzed by the researchers according to the uric acid (UA) level in drug naive de novo patients with Parkinson's disease (PD) with the intention of describing the role of anti-oxidant in cortical functional networks of PD, using functional magnetic resonance imaging (MRI). Findings illustrated that male patients with highest UA level (PD-H-UA) presented with higher cortical functional connectivity (FC) compared to the control subjects. On the other hand, female patients had lower cortical FC irrespective of UA level within all seeds. Therefore, it was deduced that RSN could be closely and gender-specifically related to the status of serum UA in de novo PD patients.