Rathfoot C, Edrissi C, Sanders CB, et al. - In this population based cross sectional study, experts aspired to explore whether there is a gender-based disparity in acute ischemic stroke (AIS) patients with baseline atrial fibrillation (AF) and whether such a discrepancy is correlated with specific risk factors and comorbidities. In total, 5,469 AIS patients (2,662 males and 2,807 females) were identified. The findings show that in the AIS patients with atrial fibrillation, migraines, HDL, LDL and poor ambulation were correlated with females, whereas drugs and alcohol, sleep apnea, and serum creatinine level were related to male AIS patients with AF. Improved baseline risk factor management strategies for AIS patients with a history of AF will benefit both males and females AIS patients with AF.