Sanchez-Autet M, et al. - This study was performed to investigate the gender differences in C-reactive protein and homocysteine modulation of cognitive performance and real-world functioning in bipolar disorder. Researchers found a gender difference in biomarker modulation of cognition and psychosocial functioning. In order to ensure an optimal outcome, a gender-based approach to cognition and real-world functioning ought to be considered in bipolar disorder.