Oh YS, et al. - Because high levels of uric acid (UA) have been shown to have a neuroprotective effect in Parkinson disease (PD) by inhibiting nigrostriatal oxidative stress, researchers explored the connection between striatal dopamine activity and UA level. The study sample consisted of 213 early PD patients. Using the median UA level, all patients were stratified into either the lower UA group or the higher UA group. In female patients, a smaller reduction in dopamine transporter uptake in the posterior putamen was observed in the higher UA level group, whereas in male patients there was no such connection. This finding indicates that UA has a neuroprotective impact, as demonstrated by female striatal dopamine activity that is relatively preserved.