Akil S, et al. - In patients with suspected or established stable ischemic heart disease, researchers assess the diagnostic performance of exercise-induced ST response in relation to findings by myocardial perfusion single photon emission computed tomography (MPS), with focus on gender differences. In this retrospective study, a gender difference in the diagnostic performance of ST response at stress, with a significantly lower PPV in females compared to males is observed in patients who have performed exercise stress test (EST) in conjunction with MPS. In addition to the ST response, specificity can be significantly improved, and a higher PPV can be obtained for both genders, while the sensitivity might be compromised by considering more EST variables.