Li X, Lin S, Wang Z, et al. - Since the pathophysiological mechanism(s) of gastroesophageal reflux disease (GERD)-related chronic cough (CC) is not clear, researchers identified the mechanism of reflux-induced cough by synchronous monitoring of reflux episodes, esophageal motility, and cough. The study sample consisted of 31 patients with GERD-CC and 47 with GERD. Investigators found that GERD-CC patients had higher reflux symptom scores, longer exposure to acid, higher DeMeester scores, and more frequent reflux episodes, proximal extent reflux detected by impedance, and a higher percentage of strongly acidic reflux compared with patients in the GERD group. In patients with GERD, proximal acidic reflux and distal reflux-reflex are jointly linked to reflux-induced cough. In GERD-associated chronic cough, low pan-esophageal pressure in primary peristalsis and synchronous contraction in secondary peristalsis can play a significant role.