Itami H, Morita K, Nakai T, et al. - Researchers examined whether and how gastritis cystica profunda (GCP) is related to gastric cancer. From 1,432 patients receiving surgery or endoscopic submucosal resection, gastric cancer specimens were obtained and grouped as GCP or non‐GCP. The two groups were compared as well as GCPs vs normal pyloric glands, in terms of clinicopathological characteristics, immunohistochemistry and in situ hybridization expression of p53, Ki‐67, KCNE2, Epstein–Barr virus (EBV) and programmed death ligand 1. In the GCP group, no cancerous lesions were identified within the GCPs, but 13% were associated with GCPs and 60.2% were found to be located above or near GCPs. Based on the findings, experts although suggested GCP as paracancerous, a high proliferation activity in GCP was revealed as well as gastric cancer with GCP was found to be related to aberrant p53 and EBV. An association of GCP with aberrant p53 expression and EBV was also observed.