Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric type
Virchows Archiv Jun 04, 2018
Yamanoi K, et al. - Given decreased expression of α1,4-linked N-acetylglucosamine (αGlcNAc) relative to MUC6 has been previously shown by researchers in gastric and pancreatic neoplasms but its significance in cervical glandular lesions remained unclear, they conducted this current investigation wherein they analyzed MUC5AC, MUC6, αGlcNAc, and p16 expression in 9 lesions of mucinous carcinoma, gastric type with minimal deviation adenocarcinoma (GAS-MDA), 5 of GAS with nonMDA (GAS-nonMDA), 14 of typical lobular endocervical gland hyperplasia (LEGH), and 5 of atypical LEGH (33 total lesions). As per findings, αGlcNAc expression decreased as typical LEGH progressed to GAS. The utility of immunohistochemical analysis of αGlcNAc and MUC6 was proposed given the difficulty in distinguishing MDA and atypical LEGH from typical LEGH in H.E. staining.
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