Paccou J, Martignène N, Lespessailles E, et al. - In this study, the risk of major osteoporotic fracture (MOF; hip, proximal humerus, wrist and distal forearm, and clinical spine) was tested in bariatric surgery patients versus matched controls. Researchers applied records from the French National Inpatient database between 2008 and 2018. Between January 1, 2010 and December 31, 2014, they compared bariatric surgery patients, aged 40 to 65 years, with BMI ≥ 40 kg/m² to one control in 1:1 ratio by age, gender, Charlson comorbidity index, year of inclusion, and class of obesity (40 to 49.9 kg/m² vs ≥ 50 kg/m²). The study population consisted of 81,984 patients 40,992 in the bariatric surgery group, and 40,992 matched controls). The study found an elevate in risk of MOF was for gastric bypass only (HR 1.70; 95% CI, 1.46–1.98) compared with the matched controls. Data indicated that gastric bypass but not sleeve gastrectomy or the other procedures increased risk of major osteoporotic fractures in patients aged 40 to 65 years.