Vergouwen MDI, et al. - Through a longitudinal study of all 57 subjects from the University Medical Center Utrecht, the Netherlands who were 18 years of age or older with ≥1 unruptured aneurysm, the researchers examined whether aneurysm wall enhancement was correlated with an increased risk of aneurysm instability. Sixty-five unruptured intracranial aneurysms were assessed. Growth or rupture was seen in 4 of 19 aneurysms with wall enhancement and in zero of 46 aneurysms without enhancement, after a median follow-up of 27 months. Therefore, an association of the gadolinium enhancement of the aneurysm wall on MR imaging with an elevated risk of aneurysm instability was noted. In the short term, the absence of wall enhancement made it doubtful that the aneurysm would grow or rupture. Moreover, in order to examine whether aneurysm wall enhancement is an independent predictor of aneurysm instability, more extensive studies are required.