Cheung CKY, Lan LL, Chan Y, et al. - In patients with functional dyspepsia (FD) without previous infection, researchers ascertained if genetic predisposition in altered biomarkers influences dyspeptic, sleep, and mood symptoms. For this investigation, consecutive adult FD patients (Rome III) were employed for upper endoscopy with no latest history of gastroenteritis and asymptomatic age- and sex-matched healthy controls. Patients with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous H pylori infection, psychiatric disorder, and recent use of NSAID or PPI have been excluded. The genetic connections with dyspeptic symptoms, sleep quality, and mood symptoms were assessed. In TRPV1, TGFB1, TNF, COMT, BDNF, IL6, IL8, IL10, and IL12, genetic polymorphisms were evaluated. Twenty-nine male patients with FD and 104 female patients with FD were age-matched (±3 years) with 81 healthy individuals. An allele in RS4803455 was linked to higher HADS depression score and epigastric burning sensation. Findings suggested that dyspeptic patients predispose genetic difference in TGFB1 that may affect dyspepsia severity.