Hurria A, et al. - In this secondary analysis of the Cancer and Leukemia Group B (CALGB) 49907 prospective randomized clinical trial, researchers compared self-reported physical function data from before and after receipt of adjuvant chemotherapy in older women with breast cancer (N=256; mean age 71.5, range 65–85). They found that, these patients commonly experienced functional decline. Recovery of physical function was seen in half of the patients, a clinically meaningful decline was observed at 12 months in one-third of the patients. Pretreatment fatigue was identified as a risk factor for functional decline from before to the end of chemotherapy. Pretreatment dyspnea and being unmarried were identified as risk factors for functional decline at 12 months. These data suggest the need for strategies to prevent functional decline in older adults receiving chemotherapy.