Berardi G, et al. - In this work, a full laparoscopic anatomical segment 8 resection focusing on the technical aspects of the Glissonian approach, is reported. A 3-cm hepatocellular carcinoma in segment 8 was detected in a routine follow-up CT scan of an 80-year-old woman affected by hepatitis C-related liver cirrhosis. Researchers assessed the liver anatomy, the relationship of the lesion with major vessels, and the borders of segment 8 via performing three-dimensional reconstruction. They used selective occlusion of segment’s 8 Glissonian pedicle, which was identified from the liver hilum, to perform a true anatomical segmentectomy. They used indocyanine green (ICG) dye demarcation as guidance during parenchymal transection. An uneventful postoperative course and discharge home following 8 days were reported for the case. They identified full laparoscopic anatomical segment 8 resection as a technically challenging operation that may be performed using Glissonian approach and with the help of ICG dye guidance. However, to complete such a difficult procedure safely, advanced laparoscopic skills are essential.