Ye H, et al. - In this study, using full high-throughput sequencing, bioinformatics, and various other methods, investigators examined the data to estimate the mechanisms of action along with variations in the expression profiles of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE). They reported profiles of 1087 lncRNAs, 102 miRNAs, and 4101 mRNAs in peripheral blood mononuclear cells (PBMCs) significantly varied between SLE cases and healthy controls. They found that the 23 lincRNAs acted on 704 target genes when cis- and trans-effects were evaluated. They also noticed gender-dependence of the differential expression of lncRNAs in SLE cases. A robust "IFN signature" was presented by candidates with SLE. Due to a variance in the number of a cell type, PBMCs exhibited differential expression of lncRNAs. Overall, they implied vital biological functions of specific lncRNAs in the pathogenesis of lupus and in suggesting directions for diagnosis and treatment of disease.