Zweerings J, et al. - In order to find the neurobiological foundations of altered mismatch processing in major depression (MD), investigators conducted functional magnetic resonance imaging (fMRI) study involving 50 participants. Of these participants, 25 had MD and 25 were matched healthy individuals and all completed an auditory mismatch paradigm optimized for fMRI. Lowered activation in the right auditory cortex and in a fronto-parietal attention network were linked with mismatch processing. Altered attention mechanisms in depression were presumably mirrored by hyposensitivity in a fronto-parietal network. By lowering the capacity of affected individuals to give attention toward important environmental cues the impairments seen may contribute to psychopathology.