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Frequency and phenotype of type 1 diabetes in the first six decades of life: A cross-sectional, genetically stratified survival analysis from UK Biobank

The Lancet Diabetes & Endocrinology Jan 29, 2018

Thomas NJ, et al. - This cross-sectional study was performed to examine the frequency and phenotype of type 1 diabetes resulting from high genetic susceptibility in the first 6 decades of life. As per the outcomes, genetic susceptibility to type 1 diabetes resulted in non-obesity-related, insulin-dependent diabetes, which presented throughout the first 6 decades of life. The outcomes underscored the difficulty of identifying type 1 diabetes after age 30 years due to the increasing background prevalence of type 2 diabetes. As these patients rapidly develop insulin dependency, failure to diagnose late-onset type 1 diabetes could have serious consequences.
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