Hemani SA, et al. - In this study, clinical data for children (age ≤ 18 years) admitted to a large hospital system for atopic dermatitis (AD) with presumed skin infection from January 2004 to December 2018 were retrospectively assessed for determining the clinical features of eczema herpeticum (EH) and its frequency of codetection with Staphylococcus aureus or group A streptococcus (GAS) in children hospitalized for presumed AD skin infection. They identified encounters with herpes simplex virus testing as AD with EH (ADEH+) or without (ADEH−). Researchers encountered 180 cases of AD with suspected skin infection; of these, 133 (74%) were tested for herpes simplex virus. Following clinical findings were linked with ADEH+ status (n = 61): fever on admission (59% vs 32% in ADEH−), rash on the neck (30% vs 13%) and vesicular rash (70% vs 49%). They observed a longer hospital length of stay in encounters in the ADEH+ group vs encounters in the ADEH− group [median 4 days (interquartile range 3–5 days) vs 3 days (interquartile range 2–3 days)]. In view of these findings, they recommend providers to hold a high index of suspicion for EH in children admitted for presumed AD skin infection. They identified a more common association of GAS with ADEH− encounters.