Freezing of all embryos in in vitro fertilization (IVF) is beneficial in high responders, but not normal and low responders: An analysis of 82,935 cycles from the SART registry
Fertility and Sterility Sep 09, 2017
Acharya KS, et al. - This study is performed to evaluate IVF and pregnancy outcomes in patients having their first frozen embryo transfer (FET) after a freeze-all cycle versus similar patients having their first fresh transfer, dividing patients based on the number of oocytes retrieved. These outcomes show that a freeze-all strategy is helpful for pregnancy outcomes in high responders with 15 or more oocytes retrieved. However, in normal (6-14 OR) and low responders (<6 OR), clinical pregnancy rate (CPR) and live birth rate (LBR) are superior following fresh embryo transfer. By making use of largest and most recent national database available, they disprove the current idea that freeze-all cycles may be beneficial for all patients regardless of ovarian response to stimulation.
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