Chen P, et al. - In a population-based cohort study, researchers analyzed the relationship between nonalcoholic fatty liver disease (NAFLD) and free triiodothyronine (FT3) in euthyroid subjects. A total of 3144 euthyroid subjects were selected for cross-sectional analysis in the baseline of the Shanghai Nicheng Atherosclerosis Study, and 2089 subjects were selected for longitudinal analysis after 2.2 years. They observed that FT3 levels increased with the occurrence of NAFLD and decreased with the remission of NAFLD in euthyroid women after a 2.2-year follow-up. In euthyroid women, there are positive associations of FT3 levels with NAFLD and the risk of NAFLD progression. Changes in FT3 levels with changes in the status of NAFLD can be an adaptive response to maintain energy and metabolic homeostasis.