Frailty is associated with a higher risk of developing delirium and cognitive impairment among patients with diabetic kidney disease: A longitudinal population‐based cohort study
Diabetic Medicine Apr 01, 2021
Lee SY, Wang J, Chao CT, et al. - The present study was performed to evaluate if the presence of frailty elevates the risk of delirium and cognitive impairment among patients with diabetic kidney disease (DKD). Adults with DKD were distinguished from the longitudinal cohort of diabetes patients (n = 840,000), dividing them into those without and with different severities of frailty based on the FRAIL scale. Researchers applied Cox proportional hazard regression to analyze the frailty‐associated risk of delirium/cognitive impairment, identified using approaches validated by others. They identified a total of 149,145 patients with DKD (mean 61.0 years, 44.2% female), among whom 31.0% did not have DKD, while 51.7%, 16.0%, and 1.3% had 1, 2, and > 2 FRAIL items at baseline. Among patients with DKD, frailty significantly increased the risk of delirium/cognitive impairment. In these patients, frailty screening may assist in delirium risk stratification.
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