Henry RK, Reeves RA, Wackym PA, et al. - In this large population-level analysis, researchers sought to evaluate the validity of the 5‐factor modified frailty index (mFI‐5) as a predictor of perioperative morbidity and mortality in patients undergoing skull base surgery. From 2005 to 2018, the National Surgical Quality Improvement Program database was used to measure a mFI5 score for patients undergoing skull base surgeries. In total, 17,912 patients who underwent skull base procedures have been identified, with 45.5% of patients having a frailty score of one or greater; 44.9% were male and the mean age was 52.0 (± 16.1 SD) years. Following skull base surgeries, frailty has an important and stepwise correlation with life-threatening postoperative morbidity, mortality, and length of stay. mFI‐5 is an objective and easily computable measure of preoperative risk that may facilitate perioperative planning and advice on outcomes prior to surgery.