Venado A, Kolaitis NA, Huang CY, et al. - Researchers investigated causes of persistent or emergent frailty after lung transplantation. Further, they examined if such transplant-related frailty is associated with key outcomes. They repeatedly evaluated 259 adults (56% male; mean age 55.9±12.3 years) for prospective measures of frailty and health-related quality of life (HRQL) for up to 3 years after lung transplantation. Outcome analysis revealed association of transplant-related frailty with lower HRQL and higher mortality in lung recipients. Frailty development after transplantation may be attributable to abnormal body composition, malnutrition and renal dysfunction. Verifying the role of these potential contributors and developing interventions to reduce frailty may enhance lung transplant success.