Wiepjes CM, de Blok CJM, Staphorsius AS, et al. - Researchers contrasted the fracture incidence in transgender people using long-term hormonal treatment (HT) with an age-matched reference population. For this nationwide cohort study, all adult transgender people at the gender identity clinic who began HT before 2016 were involved and connected to a random population-based sample of 5 age-matched reference males and 5 age-matched reference females per individual. The study sample consisted of 1,089 trans women < 50 years (mean 38 ± 9) and 934 trans women ≥ 50 years (mean 60 ± 8) using HT for median 8 (IQR 3-16) and 19 (IQR 11-29) years, respectively. Compared with age-matched reference men, fracture risk was higher in older trans women. Fracture risk tended to be increased vs age-matched reference women in young trans women. In young trans men, the risk of fracture was not increased.