Attard CC, Cameron-Pimblett A, Puri D, et al. - In this cross-sectional observational study involving 267 women with Turner syndrome (TS), median age 34.3 years, and 67 women with premature ovarian insufficiency (POI), median age 28.1 years, researchers evaluated fracture history and bone mineral density (BMD). For this investigation, they used a questionnaire to gather data on fracture history, co-morbidities and drug history including age at first oestrogen exposure. In women with TS and POI, the overall fracture rate was comparable. Women with TS had more fractures at major osteoporotic fractures (MOF) sites and fewer phalangeal fractures vs those with POI. There was no difference in BMD between women who had a fracture vs those who had not. Findings suggested no association of TS with an overall excess risk of bone fracture. In women with TS, the higher rate of fractures at MOF sites may be secondary to hearing impairment, thin cortical bone and abnormal bone remodelling.