Biolchi A, Tomei S, Santini L, et al. - Worldwide, most meningitis outbreaks are caused by Neisseria meningitidis serogroup B (MenB). Researchers here examined if the 4-component MenB vaccine (4CMenB) can induce bactericidal activity against outbreak strains in adolescents. Using a human complement serum bactericidal antibody assay (hSBA), they assayed individual sera from 20 United States and 23 Chilean adolescents who received 2 doses of 4CMenB 2 months apart at prevaccination and 1 month after second dose against a full or subset strain panel comprising 14 MenB outbreak strains and 1 MenW hyperendemic strain obtained between 2001 and 2017 in the United States, United Kingdom, and France. This study is identified to be the first work evaluating bactericidal activity elicited by a MenB vaccine against 15 outbreak strains. Bactericidal activity is elicited by two doses of 4CMenB against MenB outbreak strains and a hyperendemic MenW strain.