Perakakis N, et al. - Researchers investigated the data to estimate the significance of follistatin (FST) and its homologous protein, follistatin-like 3 (FSTL3) in glucose regulation in healthy and obese people. They noticed a decline in circulating FST after intravenous or oral glucose intake compared to controls, indicating the presence of a negative feedback mechanism among healthy candidates. A reduction in insulin resistance, glycemia, circulating FST and FSTL3 by 22%-33% after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy was observed in morbidly obese individuals. After 3 months of bariatric surgery, the variations in circulating FST were found associated with the changes in glucose, insulin, HOMA-IR, and HbA1c observed 6 months postoperatively in individuals with and without type 2 diabetes.