Masciangelo R, Chiti MC, Philippart C, et al. - Via this prospective experimental study, researchers aimed at describing ovarian tissue from pediatric patients by evaluating development and vascularization in follicle populations. In addition, they compared the tissue with adult tissue after xenografting. Hematoxylin and eosin staining, immunofluorescence, and transmission electron microscopy (TEM) evaluation were performed before and after grafting. Participants were five children (median age 3 years) and seven women (median age 28 years). Findings revealed statistically significant disparities in follicle density between pediatric and adult patients. Pediatric vs adult patients had statistically significantly higher follicle density; even though it reduced in both groups after transplantation, it remained higher in pediatric patients. The follicle proportions were, however, similar before and after grafting, with the exception of atretic and abnormal follicles. Pediatric tissue vs adult tissue had more and larger immature vessels, and the posttransplantation revascularization process is accelerated in this group.