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Folic acid supplement use and increased risk of gestational hypertension

Hypertension May 15, 2020

Li Q, Xu S, Chen X, et al. - Researchers examined the correlation of using folic acid (FA) supplements with gestational hypertension (GH) and preeclampsia. From the Tongji Maternal and Child Health Cohort, that assessed 4,853 participants for whom information on periconceptional FA supplement use and diagnosis of GH/preeclampsia were available. Among these participants, 1,161 (23.9%) were diagnosed with GH and 161 (3.3%) with preeclampsia. Women who used ≥ 800 µg/d FA supplement from prepregnancy through midpregnancy were noted to be at higher risk of developing GH than nonusers. No significant association was identified between FA supplement use and preeclampsia regardless of adjustment. Findings thus emphasize avoiding the potential risk of GH due to inappropriate FA supplement use in women who are planning or capable of pregnancy.

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