Araghi SO, et al. – In the B-PROOF trial, researchers investigated the impact of long-term daily folic acid and vitamin B12 supplementation on the incidence of overall cancer and colorectal cancer among 2,524 participants. Using the Netherlands cancer registry, they obtained and analyzed information on cancer incidence. They observed an increased risk of colorectal cancer in association with daily folic acid and vitamin B12 supplementation. In addition, a higher risk of overall cancer (171 [13.6%] vs. 143 [11.3%]; HR 1.25; 95% CI: 1.00–1.53, P=0.05) was observed in relation to allocation to B vitamins. They also noted a significant association of B vitamins with a higher risk of colorectal cancer (43 [3.4%] vs. 25 [2.0%]; HR 1.77; 95% CI: 1.08–2.90; P=0.02).