Kao Y, et al. - A systematic review and meta-analysis was done to compare the efficacies of hyperosmotic and isoosmotic solutions in restoring hemodynamic stability after burn injuries. The hyperosmotic group exhibited a significant decrease in fluid load at 24 hours postinjury compared with isoosmotic group, with a mean difference of -0.54. Findings thereby suggest hyperosmotic fluid resuscitation to be an attractive choice for severe burns in terms of total body surface area [TBSA] or burn depth.