Andersson A, et al. - In children with multiple organ failure, whether there exists a link between the ability to achieve a negative fluid balance during the first 3 continuous renal replacement therapy (CRRT) days and mortality was investigated in this retrospective cohort study with 63 patients (age 0-18 years). The study sample had a median age of 4 months. A 29% PICU mortality was reported. At CRRT initiation, significantly lower degree of fluid overload (FO) was present in survivors vs non-survivors. In critically ill children receiving CRRT, an improved patient outcome was reported in relation to early fluid removal. FO in critical illness can be avoided by taking prompt measures.