Scholten-Peeters GGM, et al. - Researchers sought to comprehensively assess mechanical sensitivity in both cephalic regions (temporalis, upper trapezius, and C1 paraspinal muscles) and extra-cephalic regions (extensor carpi radialis and tibialis anterior muscle) during the preictal, ictal, postictal and interictal phases of the migraine cycle. Further, they compared these findings with mechanical sensitivity at corresponding time-points and locations in healthy participants. In this prospective longitudinal study, they evaluated pressure pain thresholds using a digital algometer during the four phases of the migraine cycle in 19 people with migraine and at corresponding intervals and locations in 19 healthy participants. Relative to healthy participants, people with migraine exhibit increased mechanical sensitivity in cephalic and extra-cephalic regions in all phases of the migraine cycle. Furthermore, more severe mechanical sensitivity was noted in the preictal, ictal and postictal phase vs the interictal phase in cephalic and extra-cephalic regions. Findings thereby suggest localized as well as widespread mechanical sensitivity in people with migraine vs healthy participants.