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Flat-detector CT to quantify response to intra-arterial spasmolytic therapy for cerebral vasospasm

Journal of Neuroimaging Oct 27, 2019

O'Connor KP, et al. - In this prospective study at a single institution between October 5, 2017, and June 3, 2019, that explores cerebral blood volume (CBV) studies from the Artis Q biplane (Siemens), experts intended to expand the diagnostic assessment with CBV imaging. The perfusion both prior to and following treatment was measured in order to calculate this quantitative variation. A total of six individuals who underwent Digital Subtraction Angiography and flat-detector CT (FDCT) scans for cerebral vasospasm within the left hemisphere were enrolled. Following intra-arterial injection of 20 mg of verapamil, the average rises in blood volume for the temporal, frontal, and parietal lobes, were 59%, 22%, and 24 %, respectively. A reduction in the mean arterial blood pressure and transcranial Doppler values following treatment was seen. Summing up, from the infusion of verapamil in the setting of cerebral vasospasm, in CBV, FDCT could measure the efficiency of a shift. Moreover, the contributors consider quantifying the variation allows for reassurance of the betterment of cerebral vasospasm.
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