Ascher E, et al. - In view of the high expenses associated with catheter-directed thrombolysis with a requirement for a prolonged hospital stay that may lead to increased local and systemic hemorrhagic complications, researchers developed a fast-track protocol (FTP) five years back with the goal to restore patency during the initial session of thrombolysis, thereby decreasing costs and complications. In the FTP protocol, they included periadventitial injection of lidocaine at the venipuncture site under ultrasound guidance, contrast venography of the entire segment to be treated, mechanical suction thrombectomy of the confirmed occluded venous segment, tissue plasminogen activator infusion along the occluded segment, balloon maceration of thrombus, and venous stent placement in areas of significant stenosis. On clearance of the thrombus, anticoagulation and antiplatelet medications are prescribed to the patients. From January 2014 to February 2019, 38 patients were treated for acute iliofemoral deep venous thrombosis at their institution using the FTP who were retrospectively analyzed in this work. Outcomes support the safety and effectiveness of FTP in achieving excellent results at a relatively low cost.