Brun S, et al. - Researchers investigated a total of 20 young women with Turner syndrome (TS; mean ± SD, 22.9 ± 2.3 years of age) in a 5-year prospective setting to assess the development in blood pressure (BP) and heart rate and to determine potential influencing cofactors. A randomized, controlled clinical trial investigating two different doses of estradiol treatment—2 mg of 17β-estradiol per day and placebo or 2+2 mg 17β-estradiol per day)—was used to extract data. At the end of the study, 12 healthy age-matched young women were examined (control group). The investigators noted a remarkable increase in systolic and diastolic BP levels in late adolescence and early adulthood in those with TS. However, the reason underlying BP increases early in life in those with TS was unclear.