Jirapinyo P, et al. - Since transoral outlet reduction (TORe) is a common endoscopic treatment for individuals with weight regain after Roux-en-Y gastric bypass (RYGB) with a dilated gastrojejunal anastomosis (GJA), researchers conducted this retrospective review to evaluate the long-term effectiveness of TORe. Data on RYGB patients who had TORe for weight regain or inadequate weight loss were prospectively gathered. In total, 331 RYGB individuals had 342 TORe procedures and met the criteria for inclusion. Of these, 331, 258, and 123 individuals were eligible for 1-, 3- and 5-year follow-ups, respectively. Data reported that pre-TORe GJA size was 23.4 ± 6.0 mm, which reduced to 8.4 ± 1.6 mm after TORe. Patients reported a total weight loss of 8.5 ± 8.5%, 6.9 ± 10.1% and 8.8 ± 12.5% at 1, 3 and 5 years with follow-up rates of 83.3%, 81.8% and 82.9% respectively. No serious adverse events occurred. Overall, the authors concluded that TORe seems to be safe, effective, and durable at treating weight regain following RYGB.