Stone GW, Kappetein AP, Sabik JF, et al. - Researchers randomized 1,905 individuals with left main coronary artery disease of low or intermediate anatomical complexity (according to evaluation at the participating centers) to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, n = 948) or coronary artery bypass grafting (CABG) (CABG group, n = 957) in order to establish long-term outcomes following PCI with contemporary drug-eluting stents, in contrast with CABG. Death from any cause transpired more often in the PCI group vs the CABG group. The incidences of definite cardiovascular death and myocardial infarction were not considerably distinctive in the PCI and CABG groups. All cerebrovascular events were less prevalent following PCI vs CABG, nonetheless, the incidence of stroke was not significantly distinct across the two groups. Ischemia-driven revascularization was more prevalent following PCI vs CABG. In conclusion, no important variation between PCI and CABG was found relative to the rate of the composite outcome of death, stroke, or myocardial infarction at 5 years in individuals with left main coronary artery disease of low or intermediate anatomical complexity.