Chen C, Liu YQ, Qiu SX, et al. - Researchers used The Cancer Genome Atlas database to develop a metastasis- related mRNAs prognostic model to improve the accuracy of prediction of hepatocellular carcinoma (HCC) prognosis. They used 374 HCC samples and 50 normal samples. From the HCMBD website, they obtained metastatic-related genes at the same time. Overall 1,895 metastasis-related mRNAs were screened and 6 mRNAs were identified to be related to prognosis. A significant stratification of HCC patients into high- and low-risk groups was enabled by overall survival (OS)-related prognostic model based on 5 MRGs (TPM1,SLC2A1, CDCA8, ATG10 and HOXD9). Experts also developed a nomogram which included the 5-gene signature and clinical features, for prognostic prediction. Overall, metastasis-related mRNAs prognostic model was corroborated to have a predictable value on the prognosis of HCC, which could assist for gene targeted therapy.