Yarygina TA, et al. - Researchers performed a prospective cohort study of singleton pregnancies attending for a routine first-trimester scan when aneuploidy and small-for-gestational age (SGA) risks were accrued according to FMF algorithms in order to determine the risk of SGA and fetal growth restriction (FGR) and to examine the performance of first-trimester screening for SGA and FGR in women at false-positive high-intermediate risk for aneuploidy. They analyzed a total of 2,053 pregnancies; of these, 191 (9.3%) were at high-intermediate risk for aneuploidy (≥ 1/1,000) and 304 (14.8%) were at high risk for SGA (≥ 1/100). SGA was reported for a total of 140 (6.8%) neonates; 61 (3%) neonates exhibited FGR, 44 (2.1%) preterm SGA and 33 (1.6%) early SGA. Relative risks (95%CI) for SGA, FGR, preterm SGA, and early SGA were 6 (3.9-9), 9.2 (5.1-16.5), 13.4 (6.9-26.1) and 17.6 (8.1-38.2), respectively, for women at high risk for SGA and high-intermediate risk for aneuploidy vs those with first-trimester low risk for SGA. Among women at high-intermediate risk for aneuploidy, they identified a higher predictive performance of the SGA algorithm than the overall population (0.8 vs 0.7). These findings suggest that further screening for SGA in women with a first-trimester high-intermediate risk of aneuploidy allows stratification of risk for fetal growth disorders.