Sotiriadis A, et al. - Researchers aimed to develop a first-trimester or combined first- and second-trimester screening algorithm that could assist in predicting small-for-gestational age (SGA) and late fetal growth restriction (FGR). In this retrospective study of women with singleton pregnancy, who underwent routine first-, second- and third-trimester ultrasound assessment, a first-trimester screening model [comprising conception method, smoking status, maternal height, pregnancy-associated plasma protein-A (PAPP-A) and uterine artery mean pulsatility index (UtA-PI)] could predict 50.0% of the prenatally diagnosed and 36.7% of the overall late FGR fetuses for a 10% false-positive rate (FPR) and a model combining first- and second-trimester screening parameters (conception method, smoking status, PAPP-A, second- trimester EFW, head circumference/abdominal circumference ratio and UtA-PI) could predict 78.6% of the prenatally detected, and 59.6% of the overall late FGR fetuses, for a 10% FPR. Suboptimal prediction of SGA was noted with both first-trimester and combined screening.