Cousminer DL, et al. - The first genome-wide association study of latent autoimmune diabetes in adults (LADA) was conducted in case subjects of European ancestry vs population control subjects and assessed against both case subjects with type 1 diabetes and type 2 diabetes to help understand the suitable classification of this diabetes subtype. Although researchers noted positive genetic associations genome-wide with both type 1 and type 2 diabetes, the leading genetic signals were principally shared with type 1 diabetes. In addition, they discovered a novel independent signal at the known type 1 diabetes locus harboring PFKFB3, encoding a regulator of glycolysis and insulin signaling in type 2 diabetes and inflammation and autophagy in autoimmune disease, as well as an attenuation of key type 1–associated HLA haplotype frequencies in LADA, implying that these are factors that differentiate childhood-onset type 1 diabetes from adult autoimmune diabetes.