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First‐trimester prediction of small‐for‐gestational age in pregnancies at false‐positive high or intermediate risk for fetal aneuploidy

Ultrasound in Obstetrics & Gynecology Dec 20, 2020

Yarygina TA, Bataeva RS, Benitez L, et al. - The risk of small‐for‐gestational age (SGA) and fetal growth restriction (FGR) was examined in women with a false‐positive high or intermediate risk for aneuploidy. In addition, the performance of first‐trimester screening for SGA and FGR was tested in these women. Researchers conducted this prospective cohort study including 2,053 pregnancies in women with a singleton pregnancy attending for a routine first‐trimester scan. Of these, 191 (9.3%) were noted to be at high or intermediate risk for aneuploidy (≥ 1/1000) and 304 (14.8%) were noted to be at high risk for preterm SGA (≥ 1/100). In total, 140 (6.8%) cases of SGA, 61 (3.0%) of FGR, 44 (2.1%) of preterm SGA and 33 (1.6%) of early SGA were reported. The preterm SGA algorithm had higher predictive performance for SGA in women at high or intermediate risk for aneuploidy vs the overall population. Among women at high or intermediate risk for aneuploidy, the preterm SGA algorithm showed better predictive performance than that of the aneuploidy algorithm for SGA, preterm SGA and early SGA. Further screening for SGA aids in stratification of the risk for fetal growth disorders in women with a first‐trimester false‐positive high or intermediate risk of aneuploidy.

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