Qu Y, Lin S, Zhuang J, et al. - Among 8,379 confirmed congenital heart disease (CHD) cases and 6,918 controls from 40 healthcare centers of 21 cities in Guangdong Province, China, researchers conducted this case‐control study to evaluate the individual and joint impact of first‐trimester maternal folic acid supplementation (FAS) and multivitamin use on CHDs in offspring. According to findings, first‐trimester maternal FAS was substantially correlated with a lower risk of CHDs but not multivitamin use, and the relationship was strongest for the most severe CHD phenotypes. It is recommended that women of childbearing age supplement folic acid as soon as possible, ensuring coverage of the critical window for fetal cardiac development to prevent CHDs.