Qin N, et al. – A fine–mapping study of the major histocompatibility complex (MHC) region in 13,945 Asian individuals, was performed. Findings demonstrated seven novel bi–allelic variants and five polymorphic amino acid positions in HLA–DRβ1, HLA–DQα1, and HLA–A that conferred a risk of lung cancer. HLA class I and II molecules were substantially involved in lung cancer susceptibility.