Wu D, Chen RM, Chen SK, et al. - This is the first multicenter study in China investigating the effectiveness of growth hormone (GH) in improving final adult height (FAH) in idiopathic short status (ISS) children. Participants in the study were children (n = 344) with ISS in seven hospitals in China. Boys and girls had an average baseline age of 12.7 and 11.7 years, with bone age of 11.7 and 10.1 years, respectively. The FAH standard deviation score (SDS) was significantly increased in both boys and girls compared with the baseline height SDS. Findings suggested that both girls and boys of ISS have improved FAH through GH therapy even when treatments begin over 10 years of age and most of them have reached TH. Some ISS peri-puberty may experience a spontaneous height rise. A spontaneous catch-up growth of 1.16 SD was noted even in the control group. The authors suggest more than 2 years of GH treatment for girls and longer courses for boys.