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Fifty-year incidence of Waldenstrom macroglobulinemia in Olmsted county, Minnesota, from 1961 through 2010: A population-based study with complete case capture and hematopathologic review

Mayo Clinic Proceedings Apr 22, 2018

Kyle RA, et al. - The incidence of Waldenstrom macroglobulinemia (WM) was investigated in a strictly defined geographic area over a 50-year period among all residents of Olmsted County with a diagnosis of WM, consisting of a monoclonal IgM protein of any size and/or 10% or more lymphoplasmacytic infiltration of the bone marrow along with anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly requiring therapy. Using a smoothing spline, no convincing evidence was yielded for a change in the incidence of WM. An approximately 2-fold excess mortality was reported in subjects diagnosed with WM after 2000 compared with the expected population mortality.
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