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Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis

Respiratory Research May 17, 2018

Heukels P, et al. - Researchers investigated whether fibrocytes can be detected in Idiopathic Pulmonary Fibrosis (IPF) lungs. They compared percentages and phenotypic features of lung fibrocytes with circulating fibrocytes in IPF. As per findings, the quantification, as well as characterization of lung fibrocytes in IPF patients, can be done by flow cytometry. Compared with circulating fibrocytes, different characteristics of lung fibrocytes were identified. Moreover, lung fibrocytes represent an intermediate cell population between circulating fibrocytes and lung fibroblast and more insight in their phenotype might lead to specific therapeutic targeting in fibrotic lung diseases.
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