Dong D, et al. - Researchers compared osteoma, ossifying fibroma (OF) and fibrous dysplasia (FD) in the paranasal sinus and craniofacial regions, in terms of their clinical features in this retrospective analysis of 282 patients (112 males, 170 females) with osteoma (161), OF (44), and FD (77) involving the paranasal sinus, skull base and orbit managed surgically. They reported onset ages for osteoma, OF and FD, were 40.3, 24.5, and 15 years, respectively. Cases with osteoma vs FD demonstrated significant differences in the preoperative serum alkaline phosphatase levels. For osteoma, OF, and FD, recurrent rates were estimated to be 0%, 13.6%, and 15.6%, respectively. Overall, findings revealed that in terms of onset age, location, and recurrence rate, there were differences among osteoma, OF and FD involving the paranasal sinus and craniofacial region. The occurrence of osteoma was most common in the ethmoid sinus, while OF and FD occurred in the maxilla most and were more likely to involve the orbit and the skull base, respectively. The main means for treatment, currently, is endoscopic surgery, but developing individualized treatment regimen for patients was recommended.