Mariz BALA, et al. - For this investigation, researchers assessed fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor-1 (FGFR-1) expression in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC) as well as its link with OTSCC patients’ prognosis. They retrospectively selected 167 cases with 85 surgical specimens of patients with oral tongue squamous cell carcinoma (OTSCC), 46 incisional biopsies of OTSCC and 36 oral epithelial dysplasia (OED). In OTSCC patients, increased expression of FGF-2 and FGFR-1 was related to high-grade OEDs and were associated with metastasis presence and adverse outcomes.