Fertility preservation in Turner syndrome: Karyotype does not predict ovarian response to stimulation
Clinical Endocrinology Sep 22, 2019
Vergier J, et al. - Since Turner syndrome (TS) is liable for gonadal dysgenesis with a high risk of premature ovarian insufficiency, researchers in this population desired to know about strategies for fertility preservation (FP). From 2014 to 2018, data from TS women consulting with a fertility specialist in the FP center were collected retrospectively. Nine TS women have been referred. For oocyte vitrification, three women with different karyotypes had controlled ovarian stimulation. Mean age was 13.7 years [9-20] at TS diagnosis. According to results, AMH and FSH levels appeared to be accurate predictive markers of oocyte cryopreservation achievement regardless of karyotype, antral follicular count. With a high number of retrieved oocytes, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation in a monosomic TS woman. In the event of spontaneous menarche, TS adolescents should be referred for FP counselling during the transition to adulthood to prevent referral delay and time-related reduced ovarian reserve.
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